Behavioral Reserve in MCI and AD 

 
   Lead Investigator:    Liana Apostolova
   Institution      :    UCLA
   E-Mail           :    lapostolova@mednet.ucla.edu
   Proposal ID      :    373


   Publications:


1  Apostolova L, Tseng C, Fairbanks L, Elashoff D, Cummings J
   Effect of age, gender, marital status and education on behavioral symptoms in MCI and mild AD subjects
   Abstract  Neurology,74:A21,2010,

   PUBLISHED



2  Apostolova LG, Di LJ, Duffy EL, Brook J, Elashoff D, Tseng CH, Fairbanks L, Cummings JL
   Risk factors for behavioral abnormalities in mild cognitive impairment and mild Alzheimer's disease
   Journal Article  Dement Geriatr Cogn Disord,37:315-326,2014,PMC4057985

   PUBLISHED



3  Apostolova LG, Di LJ, Tseng CH, Fairbanks L, Elashoff D, Cummings JL
   Comparison of the prevalence of neuropsychiatric behaviors between amnestic and nonamnestic MCI subjects
   Abstract  Alzheimers Dement,8:P135,2012,

   PUBLISHED



4  Apostolova LG, Di LJ, Tseng CH, Fairbanks L, Elashoff D, Cummings JL
   Behavioral reserve in mild cognitive impairment and mild Alzheimer's disease
   Abstract  Alzheimers Dement,8:P323,2012,

   PUBLISHED





   Proposal Description:
   Behavioral symptoms are a prominent feature of Alzheimer's disease (AD) and mild cognitive impairment (MCI). They occur concomitantly with cognitive decline and progress as the disease evolves. Recent advances have suggested that subjects with higher education and occupational attainment may have more cognitive reserve and thus develop symptoms later in the disease course. Whether such phenomenon occurs for the neuropsychiatric symptoms of dementia has not been   researched. We hypothesize that highly educated individuals who are typically more acutely aware of their cognitive decline will be more susceptible to depression, anxiety, irritability and apathy relative to those with lower educational attainment and that good social network and family su will likely offer relative protection from behavioral manifestations. We also hypothesize that older subjects will suffer from more behavioral symptoms relative to younger subjects. We propose analyze the Neuropsychiatric Inventory (NPI-Q) data of patients with MCI and mild AD in logistic regression models. The results from this investigation will add new and exciting evidence for the existence of behavioral risk and protective factors in MCI and mild AD and will start the foundation of the behavioral reserve hypothesis.